Akers received a Tony nomination for her Broadway debut as Luisa Contini in the original Tommy Tune-directed production of Nine and returned to Broadway in another Tune musical, Grand Hotel. Her film roles include Mike Nichols’ Heartburn, opposite Jack Nicholson and Meryl Streep; Woody Allen’s The Purple Rose of Cairo; and Vibes, while her TV credits include Cheers, Hart to Hart, Presenting Karen Akers, and On Stage at Wolf Trap.
It's been the concert and cabaret stage where Akers has been most acclaimed. Her numerous solo recordings include Like It Was, Presenting Karen Akers, In a Very Unusual Way, Simply Styne, and If We Only Have Love. Akers is the recipient of the 2005 New York Nightlife Award for Outstanding Female Cabaret Vocalist in a Major Engagement and the 2009 Nightlife Legend Award.